Article
A Knock-In Mouse Model of Thymoma With the GTF2I L424H Mutation.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Dec 2022
He Yongfeng, Kim In-Kyu, Bian Jing, Polyzos Alexander, Di Giammartino Dafne Campigli, Zhang Yu-Wen, Luo Ji, Hernandez Maria O, Kedei Noemi, Cam Maggie, Borczuk Alain C, Lee Trevor, Han Yumin, Conner Elizabeth A, Wong Madeline, Tillo Desiree C, Umemura Shigeki, Chen Vincent, Ruan Lydia, White Jessica B, Miranda Ileana C, Awasthi Parirokh P, Altorki Nasser K, Divakar Prajan, Elemento Olivier, Apostolou Effie, Giaccone Giuseppe
Abstract excerpt
INTRODUCTION: The pathogenesis of thymic epithelial tumors remains largely unknown. We previously identified GTF2I L424H as the most frequently recurrent mutation in thymic epithelial tumors. Nevertheless, the precise role of this mutation in tumorigenesis of thymic epithelial cells is unclear. METHODS: To investigate the role of GTF2I L424H mutation in thymic epithelial cells in vivo, we generated and...
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