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Article

Quantifying Hematopoietic Stem Cell Clonal Diversity by Selecting Informative Amplicon Barcodes.

Scientific reports - 7 Feb 2020

Teets Emily M, Gregory Charles, Shaffer Jami, Blachly James S, Blaser Bradley W

Abstract excerpt

Hematopoietic stem cells (HSCs) are functionally and genetically diverse and this diversity decreases with age and disease. Numerous systems have been developed to quantify HSC diversity by genetic barcoding, but no framework has been established to empirically validate barcode sequences. Here we have developed an analytical framework, Selection of informative Amplicon Barcodes from Experimental Replicates...

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Identifiers

PMID: 32034234
DOI: 10.1038/s41598-020-59119-8
PMCID: PMC7005852

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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