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Article

Dysregulated iron metabolism in C. elegans catp-6/ATP13A2 mutant impairs mitochondrial function.

Neurobiology of disease - 1 Jun 2020

Anand Nikhita, Holcom Angelina, Broussalian Michael, Schmidt Minna, Chinta Shankar J, Lithgow Gordon J, Andersen Julie K, Chamoli Manish

Abstract excerpt

Mutations in the human ATP13A2 gene are associated with an early-onset form of Parkinson's disease (PD) known as Kufor Rakeb Syndrome (KRS). Patients with KRS show increased iron deposition in the basal ganglia, suggesting iron toxicity-induced neurodegeneration as a potential pathogenesis associated with the ATP13A2 mutation. Previously we demonstrated that functional losses of ATP13A2 disrupt the lysosomes...

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Identifiers

PMID: 32032734
DOI: 10.1016/j.nbd.2020.104786
PMCID: PMC7150649

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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