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Iron toxicity potentiates cell-type specific amyloid beta proteotoxicity in <i>C. elegans</i> via altered energy homeostasis

2026-03-27

Abstract excerpt

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by memory loss and a decline in cognitive function. Hallmarks of AD include an age-dependent accumulation of toxic amyloid beta (Aβ) 42 in the brain, energy dyshomeostasis caused by mitochondrial dysfunction, and iron overload. However, the role of iron overload and mitochondrial dysfunction in AD pathology is unknown and their prec...

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Literature Corpus work
cad09aec-11ee-59bc-b679-79a42de54428
DOI
10.64898/2026.03.25.714217
Open publication

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Iron toxicity potentiates cell-type specific amyloid beta proteotoxicity in <i>C. elegans</i> via altered energy homeostasisDOI 10.64898/2026.03.25.714217
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