Article
Presenilin mutations disrupt iron homeostasis to promote ferroptosis mediated neurodegeneration in Caenorhabditis elegans.
Redox biology - 1 Dec 2025
Ryan Kerry C, Laboy Jocelyn T, Ashraf Rabia, Ashkavand Zahra, Jayasinghe Isabel, Norman Kenneth R
Abstract excerpt
Iron is a vital trace element involved in numerous physiological processes, but it becomes toxic when present in excess. Disruption of iron balance in the brain has been linked to the development of neurodegenerative diseases such as Alzheimer's disease (AD), though the underlying mechanisms remain poorly understood. Familial forms of AD are primarily caused by mutations in presenilin, which are known to disturb...
Topics
- Animals
- Caenorhabditis elegans
- Iron
- Ferroptosis
- Homeostasis
- Mutation
- Presenilins
- Mitochondria
- Caenorhabditis elegans Proteins
- Calcium
- Neurodegenerative Diseases
- Disease Models, Animal
- Oxidative Stress