Article
Mitotic protein kinase CDK1 phosphorylation of mRNA translation regulator 4E-BP1 Ser83 may contribute to cell transformation.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jul 2016
Velásquez Celestino, Cheng Erdong, Shuda Masahiro, Lee-Oesterreich Paula J, Pogge von Strandmann Lisa, Gritsenko Marina A, Jacobs Jon M, Moore Patrick S, Chang Yuan
Abstract excerpt
Mammalian target of rapamycin (mTOR)-directed eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) phosphorylation promotes cap-dependent translation and tumorigenesis. During mitosis, cyclin-dependent kinase 1 (CDK1) substitutes for mTOR and fully phosphorylates 4E-BP1 at canonical sites (T37, T46, S65, and T70) and the noncanonical S83 site, resulting in a mitosis-specific hyperphosphorylated...
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