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Article

Altered T cell plasticity favours Th17 cells in early arthritis.

Rheumatology (Oxford, England) - 1 Oct 2020

Leipe Jan, Pirronello Fausto, Schulze-Koops Hendrik, Skapenko Alla

Abstract excerpt

OBJECTIVES: The predominance of differentiated Th17 cells has been implied as a key driver of autoimmune arthritis, including early RA. Because accumulating evidence suggests that Th cell differentiation is a plastic process, we investigated plasticity and underlying molecular mechanisms to address the shift towards the Th17 phenotype in early RA. METHODS: A cohort of 61 patients with early, active, untreated RA...

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PMID: 32030419
DOI: 10.1093/rheumatology/kez660

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