Th17 plasticity: pathophysiology and treatment of chronic inflammatory disorders.

Abstract excerpt

CD4+ T cells can be classified from a functional point of view in different lineages, the most extensively studied being the Th1, Th2, and Th17. Recent evidence suggest that the acquisition of a certain phenotype is not irreversible, and lymphocytes can acquire features of different effector fates upon adequate stimuli. In particular, Th17 lymphocytes in inflammatory conditions can start to produce IFN-γ or IL-4,...

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