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Article

VAV1-Cre mediated hematopoietic deletion of CBL and CBL-B leads to JMML-like aggressive early-neonatal myeloproliferative disease.

Oncotarget - 13 Sept 2016

An Wei, Mohapatra Bhopal C, Zutshi Neha, Bielecki Timothy A, Goez Benjamin T, Luan Haitao, Iseka Fany, Mushtaq Insha, Storck Matthew D, Band Vimla, Band Hamid

Abstract excerpt

CBL and CBL-B ubiquitin ligases play key roles in hematopoietic stem cell homeostasis and their aberrations are linked to leukemogenesis. Mutations of CBL, often genetically-inherited, are particularly common in Juvenile Myelomonocytic Leukemia (JMML), a disease that manifests early in children. JMML is fatal unless corrected by bone marrow transplant, which is effective in only half of the recipients, stressing...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27449297
DOI: 10.18632/oncotarget.10638
PMCID: PMC5312291

Genes

CBL
VAV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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VAV1-Cre mediated hematopoietic deletion of CBL and CBL-B leads to JMML-like aggressive early-neonatal myeloproliferative disease.PMID 27449297Read ↗

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