Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

shRNA screening identifies JMJD1C as being required for leukemia maintenance

6 Feb 2014

Abstract excerpt

Epigenetic regulatory mechanisms are implicated in the pathogenesis of acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL). Recent progress suggests that proteins involved in epigenetic control are amenable to drug intervention, but little is known about the cancer-specific dependency on epigenetic regulators for cell survival and proliferation. We used a mouse model of human AML induced by the MLL-AF9...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Chronic Lymphocytic Leukemia Research
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24501218
DOI: 10.1182/blood-2013-08-522094

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

shRNA screening identifies JMJD1C as being required for leukemia maintenancePMID 24501218Read ↗

Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AMLSemantic proximity Read ↗

Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia.Semantic proximity Read ↗

SETDB1 mediated histone H3 lysine 9 methylation suppresses MLL-fusion target expression and leukemic transformationSemantic proximity Read ↗

MLL leukemia induction by genome editing of human CD34+ hematopoietic cellsSemantic proximity Read ↗

Deletion of the RNA‐editing enzyme ADAR1 causes regression of established chronic myelogenous leukemia in miceSemantic proximity Read ↗

Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression.Semantic proximity Read ↗

HOXA9 is required for survival in human MLL-rearranged acute leukemias.Semantic proximity Read ↗

Loss of MBD2 attenuates MLL-AF9-driven leukemogenesis by suppressing the leukemic cell cycle via CDKN1CSemantic proximity Read ↗

The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenanceSemantic proximity Read ↗

A role for MEIS1 in MLL-fusion gene leukemiaSemantic proximity Read ↗

Jmjd1c is dispensable for healthy adult hematopoiesis and Jak2V617F-driven myeloproliferative disease initiation in mice.Semantic proximity Read ↗

A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged LeukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.