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Article

MiR-30e-3p Influences Tumor Phenotype through MDM2/TP53 Axis and Predicts Sorafenib Resistance in Hepatocellular Carcinoma.

Cancer research - 15 Apr 2020

Gramantieri Laura, Pollutri Daniela, Gagliardi Martina, Giovannini Catia, Quarta Santina, Ferracin Manuela, Casadei-Gardini Andrea, Callegari Elisa, De Carolis Sabrina, Marinelli Sara, Benevento Francesca, Vasuri Francesco, Ravaioli Matteo, Cescon Matteo, Piscaglia Fabio, Negrini Massimo, Bolondi Luigi, Fornari Francesca

Abstract excerpt

The molecular background of hepatocellular carcinoma (HCC) is highly heterogeneous, and biomarkers predicting response to treatments are an unmet clinical need. We investigated miR-30e-3p contribution to HCC phenotype and response to sorafenib, as well as the mutual modulation of TP53/MDM2 pathway, in HCC tissues and preclinical models. MiR-30e-3p was downregulated in human and rat HCCs, and its downregulation...

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PMID: 32015093
DOI: 10.1158/0008-5472.CAN-19-0472

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