Article
A distinct sortase SrtB anchors and processes a streptococcal adhesin AbpA with a novel structural property.
Scientific reports - 5 Aug 2016
Liang Xiaobo, Liu Bing, Zhu Fan, Scannapieco Frank A, Haase Elaine M, Matthews Steve, Wu Hui
Abstract excerpt
Surface display of proteins by sortases in Gram-positive bacteria is crucial for bacterial fitness and virulence. We found a unique gene locus encoding an amylase-binding adhesin AbpA and a sortase B in oral streptococci. AbpA possesses a new distinct C-terminal cell wall sorting signal. We demonstrated that this C-terminal motif is required for anchoring AbpA to cell wall. In vitro and in vivo studies revealed...
Topics
- Amino Acid Motifs
- Aminoacyltransferases
- Bacterial Adhesion
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
- Cell Wall
- Cysteine Endopeptidases
- Host-Pathogen Interactions
- Microorganisms, Genetically-Modified
- Mouth