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Article

Cyp1 Inhibition Prevents Doxorubicin-Induced Cardiomyopathy in a Zebrafish Heart-Failure Model.

Chembiochem : a European journal of chemical biology - 1 Jul 2020

Lam Pui-Ying, Kutchukian Peter, Anand Rajan, Imbriglio Jason, Andrews Christine, Padilla Hugo, Vohra Anita, Lane Sarah, Parker Dann L, Cornella Taracido Ivan, Johns Douglas G, Beerens Manu, MacRae Calum A, Caldwell John P, Sorota Steve, Asnani Aarti, Peterson Randall T

Abstract excerpt

Doxorubicin is a highly effective chemotherapy agent used to treat many common malignancies. However, its use is limited by cardiotoxicity, and cumulative doses exponentially increase the risk of heart failure. To identify novel heart failure treatment targets, a zebrafish model of doxorubicin-induced cardiomyopathy was previously established for small-molecule screening. Using this model, several small molecules...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32003101
DOI: 10.1002/cbic.201900741
PMCID: PMC7500981

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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