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Article

Zebrafish Model Reveals Early Electrocardiographic and Molecular Signatures of Doxorubicin-Induced Cardiotoxicity.

Cardiovascular toxicology - 13 Apr 2026

Lai Zih-Yin, Lee Chi-Ying, Chiu Yu-Ching, Lin Chia-Hung, Yang Chung-Chi, Ho Chia-Chia, Liu Lawrence Yu-Min, Chuang Yung-Jen

Abstract excerpt

Doxorubicin (DOX) is a highly effective anthracycline widely used in cancer therapy but limited by its dose-dependent cardiotoxicity, which may result in arrhythmia, dilated cardiomyopathy, and heart failure. Conventional surveillance tools, including echocardiography and serum biomarkers, often identify injury only after substantial cardiac dysfunction has occurred. This underscores the need for early markers...

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Identifiers

PMID: 41968204
DOI: 10.1007/s12012-026-10113-y
PMCID: PMC13070985

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