Article
Retrospective Cohort: Genomic Differences Between Pigmented Spindle Cell Nevi of Reed and Reed-Like Melanomas.
The American Journal of dermatopathology - 1 Sept 2020
Mohan Lauren S, Khan Ayesha U, Zhang Bin, Quan Victor L, Shi Katherine, Panah Elnaz, Isales Maria Cristina, Yazdan Pedram, Zhang Yongzhan, Beaubier Nike, Taxter Timothy J, Compres Elsy V, Kim Daniel, White Kevin P, Gerami Pedram
Abstract excerpt
BACKGROUND: Some melanomas closely resemble pigmented spindle cell nevi (PSCN) of Reed histologically. The distinction of these entities is important for clinical management. A recent study showed most PSCN (78%) are fusion-driven, commonly involving NTRK3 (57%). Conversely, BRAF V600E mutations are not characteristic of PSCN but are frequent in melanoma. OBJECTIVE: In this study, we assessed clinical, histologic...
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