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Article

Genomic and Clinicopathologic Characteristics of PRKAR1A-inactivated Melanomas: Toward Genetic Distinctions of Animal-type Melanoma/Pigment Synthesizing Melanoma.

The American journal of surgical pathology - 1 Jun 2020

Cohen Jarish N, Yeh Iwei, Mully Thaddeus W, LeBoit Philip E, McCalmont Timothy H

Abstract excerpt

Melanocytic tumors with inactivation of protein kinase A regulatory subunit-α (PRKAR1A) have large oval nuclei and intense pigmentation. Historically, these tumors have been categorized under various names, including epithelioid blue nevus, pigmented epithelioid melanocytoma (PEM) and animal-type melanoma. Although a subset of PEM harbor BRAF activating mutations and biallelic inactivation of PRKAR1A, there are...

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PMID: 32118628
DOI: 10.1097/PAS.0000000000001458

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