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Article

Personalized Treatment of H3K27M-Mutant Pediatric Diffuse Gliomas Provides Improved Therapeutic Opportunities

10 Jan 2020

Abstract excerpt

Diffuse gliomas with K27M histone mutations (H3K27M-glioma) are generally characterized by a fatal prognosis, particularly affecting the pediatric population. Based on the molecular heterogeneity observed in this tumor type personalized treatment is considered to substantially improve therapeutic options. Therefore, clinical evidence for therapy, guided by comprehensive molecular profiling is urgently required....

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PMID: 31998633
DOI: 10.3389/fonc.2019.01436

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