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Article

Synergistic defects in pre-rRNA processing from mutations in the U3-specific protein Rrp9 and U3 snoRNA.

Nucleic acids research - 17 Apr 2020

Clerget Guillaume, Bourguignon-Igel Valérie, Marmier-Gourrier Nathalie, Rolland Nicolas, Wacheul Ludivine, Manival Xavier, Charron Christophe, Kufel Joanna, Méreau Agnès, Senty-Ségault Véronique, Tollervey David, Lafontaine Denis L J, Branlant Christiane, Rederstorff Mathieu

Abstract excerpt

U3 snoRNA and the associated Rrp9/U3-55K protein are essential for 18S rRNA production by the SSU-processome complex. U3 and Rrp9 are required for early pre-rRNA cleavages at sites A0, A1 and A2, but the mechanism remains unclear. Substitution of Arg 289 in Rrp9 to Ala (R289A) specifically reduced cleavage at sites A1 and A2. Surprisingly, R289 is located on the surface of the Rrp9 β-propeller structure opposite...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31996908
DOI: 10.1093/nar/gkaa066
PMCID: PMC7144924

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