Article
Xenopus U3 snoRNA docks on pre-rRNA through a novel base-pairing interaction.
RNA (New York, N.Y.) - 1 Jun 2004
Borovjagin Anton V, Gerbi Susan A
Abstract excerpt
U3 small nucleolar RNA (snoRNA) is essential for rRNA processing to form 18S ribosomal RNA (rRNA). Previously, it has been shown that nucleolin is needed to load U3 snoRNA on pre-rRNA. However, as documented here, this is not sufficient. We present data that base-pairing between the U3 hinges and the external transcribed spacer (ETS) is critical for functional alignment of U3 on its pre-rRNA substrate....
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