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Article

The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jun 2006

Bleichert Franziska, Granneman Sander, Osheim Yvonne N, Beyer Ann L, Baserga Susan J

Abstract excerpt

Ribosome biogenesis is a complex process that requires >150 transacting factors, many of which form macromolecular assemblies as big and complex as the ribosome itself. One of those complexes, the SSU processome, is required for pre-18S rRNA maturation. Although many of its components have been i...

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Identifiers

PMID: 16769905
DOI: 10.1073/pnas.0603673103
PMCID: PMC1480430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16769905-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation.PMID 16769905Read ↗

hUTP24 is essential for processing of the human rRNA precursor at site A1, but not at site A0.Semantic proximity Read ↗

Utp14 interaction with the small subunit processome.Semantic proximity Read ↗

Bud23 promotes the final disassembly of the small subunit Processome in Saccharomyces cerevisiae.Semantic proximity Read ↗

Imp3p and Imp4p mediate formation of essential U3-precursor rRNA (pre-rRNA) duplexes, possibly to recruit the small subunit processome to the pre-rRNA.Semantic proximity Read ↗

The rRNA methyltransferase Bud23 shows functional interaction with components of the SSU processome and RNase MRP.Semantic proximity Read ↗

The nucleolar protein Nop19p interacts preferentially with Utp25p and Dhr2p and is essential for the production of the 40S ribosomal subunit in Saccharomyces cerevisiae.Semantic proximity Read ↗

Synergistic defects in pre-rRNA processing from mutations in the U3-specific protein Rrp9 and U3 snoRNA.Semantic proximity Read ↗

A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing.Semantic proximity Read ↗

Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage.Semantic proximity Read ↗

The C-terminus of Utp4, mutated in childhood cirrhosis, is essential for ribosome biogenesis.Semantic proximity Read ↗

Prp43 bound at different sites on the pre-rRNA performs distinct functions in ribosome synthesis.Semantic proximity Read ↗

Crt10 directs the cullin-E3 ligase Rtt101 to nonfunctional 25S rRNA decay.Semantic proximity Read ↗

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