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Article

Population Pharmacokinetics of Sulindac and Genetic Polymorphisms of FMO3 and AOX1 in Women with Preterm Labor.

Pharmaceutical research - 28 Jan 2020

Sung Jin Won, Yun Hwi-Yeol, Park Sunny, Kim Young Ju, Yee Jeong, Lee Kyung Eun, Song Byungjeong, Chung Jee Eun, Gwak Hye Sun

Abstract excerpt

PURPOSE: This prospective study aimed to evaluate the effects of genetic polymorphisms in sulindac-related metabolizing enzyme genes including FMO3 and AOX1 on the population pharmacokinetics of sulindac in 58 pregnant women with preterm labor. METHODS: Plasma samples were collected at 1.5, 4, and 10 h after first oral administration of sulindac. Plasma concentrations of sulindac and its active metabolite...

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PMID: 31993760
DOI: 10.1007/s11095-020-2765-6

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