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Article

Effects of FMO3 Polymorphisms on Pharmacokinetics of Sulindac in Chinese Healthy Male Volunteers.

BioMed research international - 1 Jan 2017

Tang Yong-Jun, Hu Kai, Huang Wei-Hua, Wang Chong-Zhi, Liu Zhi, Chen Yao, Ouyang Dong-Sheng, Tan Zhi-Rong, Zhou Hong-Hao, Yuan Chun-Su

Abstract excerpt

Sulindac is a nonsteroidal anti-inflammatory drug, which is clinically used for the ailments of various inflammations. This study investigated the allele frequencies of FMO3 E158K and E308G and evaluated the influences of these two genetic polymorphisms on the pharmacokinetics of sulindac and its metabolites in Chinese healthy male volunteers. Eight FMO3 wild-type (FMO3 HHDD) subjects and seven FMO3 homozygotes...

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Share to Anti-Inflammatory Agents, Non-Steroidal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Restriction Fragment Length

Source

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Identifiers

PMID: 28331852
DOI: 10.1155/2017/4189678
PMCID: PMC5346382

Genes

FMO3

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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