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Article

Development of a physiologically based pharmacokinetic model to predict the effects of flavin-containing monooxygenase 3 (FMO3) polymorphisms on itopride exposure.

Biopharmaceutics & drug disposition - 1 Sept 2017

Zhou Wangda, Humphries Helen, Neuhoff Sibylle, Gardner Iain, Masson Eric, Al-Huniti Nidal, Zhou Diansong

Abstract excerpt

Itopride, a substrate of FMO3, has been used for the symptomatic treatment of various gastrointestinal disorders. Physiologically based pharmacokinetic (PBPK) modeling was applied to evaluate the impact of FMO3 polymorphism on itopride pharmacokinetics (PK). The Asian populations within the Simcyp simulator were updated to incorporate information on the frequency, activity and abundance of FMO3 enzyme with...

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PMID: 28255999
DOI: 10.1002/bdd.2074

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FMO3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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