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Article

The RUNX genes: gain or loss of function in cancer.

Nature reviews. Cancer - 1 May 2005

Blyth Karen, Cameron Ewan R, Neil James C

Abstract excerpt

The RUNX genes have come to prominence recently because of their roles as essential regulators of cell fate in development and their paradoxical effects in cancer, in which they can function either as tumour-suppressor genes or dominant oncogenes according to context. How can this family of transcription factors have such an ambiguous role in cancer? How and where do these genes impinge on the pathways that...

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PMID: 15864279
DOI: 10.1038/nrc1607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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