Two-point-NGS analysis of cancer genes in cell-free DNA of metastatic cancer patients.

doi:10.1002/cam4.2782

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Two-point-NGS analysis of cancer genes in cell-free DNA of metastatic cancer patients.

Cancer medicine - 1 Mar 2020

Palmieri Maria, Baldassarri Margherita, Fava Francesca, Fabbiani Alessandra, Gelli Elisa, Tita Rossella, Torre Pamela, Petrioli Roberto, Hadijstilianou Theodora, Galimberti Daniela, Cinotti Elisa, Bengala Carmelo, Mandalà Marco, Piu Pietro, Miano Salvatora Tindara, Martellucci Ignazio, Vannini Agnese, Pinto Anna Maria, Mencarelli Maria Antonietta, Marsili Stefania, Renieri Alessandra, Frullanti Elisa

Abstract excerpt

BACKGROUND: Although the efficacy of molecularly target agents in vitro, their use in routine setting is limited mainly to the use of anti-HER2 and antiEGFR agents in vivo. Moreover, core biopsy of a single cancer site may not be representative of the whole expanding clones and cancer molecular profile at relapse may differ with respect to the primary tumor. METHODS: We assessed the status of a large panel of...

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PMID: 31991072
DOI: 10.1002/cam4.2782
PMCID: PMC7064095

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