Article
Artemisinin and its derivatives target mitochondrial c-type cytochromes in yeast and human cells.
Biochimica et biophysica acta. Molecular cell research - 1 May 2020
Laleve Anais, Panozzo Cristina, Kühl Inge, Bourand-Plantefol Alexa, Ostojic Jelena, Sissoko Abdoulaye, Tribouillard-Tanvier Déborah, Cornu David, Burg Angélique, Meunier Brigitte, Blondel Marc, Clain Jerome, Bonnefoy Nathalie, Duval Romain, Dujardin Geneviève
Abstract excerpt
Artemisinin and its derivatives kill malaria parasites and inhibit the proliferation of cancer cells. In both processes, heme was shown to play a key role in artemisinin bioactivation. We found that artemisinin and clinical artemisinin derivatives are able to compensate for a mutation in the yeast Bcs1 protein, a key chaperon involved in biogenesis of the mitochondrial respiratory complex III. The equivalent Bcs1...
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