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Article

PIK3CA gene mutations in the helical domain correlate with high tumor mutation burden and poor prognosis in metastatic breast carcinomas with late-line therapies.

Aging - 24 Jan 2020

Tang Yu, Li Jing, Xie Ning, Yang Xiaohong, Liu Liping, Wu Hui, Tian Can, He Ying, Wang Xiao, He Qiongzhi, Hu Zhe-Yu, Ouyang Quchang

Abstract excerpt

Nearly half of metastatic breast cancers (MBC) have genetic aberrations in the PI3K/AKT pathway. To investigate the distinct effect of these aberrations on MBC, 193 MBC patients who progressed after the early line (≤2) salvage treatment voluntarily received next generation sequencing (NGS) for a panel of 1,021 genes. 93 (48%) patients had genetic aberrations in the PI3K/AKT pathway. The number of patients with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31980592
DOI: 10.18632/aging.102701
PMCID: PMC7053638

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