Article

PIK3CA Mutation is Associated with Poor Response to HER2-Targeted Therapy in Breast Cancer Patients

2022-01-18

Abstract excerpt

<title>Abstract</title> <p><bold>Purpose</bold>Mutations in <italic>PIK3CA</italic> gene occur frequently in patients with breast cancer. Activating <italic>PIK3CA</italic> mutations have been shown to confer resistance to human epidermal growth factor receptor (HER)2-targeted treatments. In this retrospective study, we investigated whether <italic>PIK3CA</italic> mutations were correlated with treatment response...

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Literature Corpus work: 71648514-2151-5569-b277-3040d77901d9
DOI: 10.21203/rs.3.rs-1259287/v1

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