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Article

Neuron-specific Kv1.1 deficiency is sufficient to cause epilepsy, premature death, and cardiorespiratory dysregulation

21 Jan 2020

Abstract excerpt

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality, but the precise cellular substrates involved remain elusive. Epilepsy-associated ion channel genes with co-expression in brain and heart have been proposed as SUDEP candidate genes since they provide a singular unifying link between seizures and lethal cardiac arrhythmias. Here, we generated a conditional knockout...

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Share to Cardiac electrophysiology and arrhythmias
Share to Epilepsy research and treatment
Share to Ion channel regulation and function

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PMID: 31978607
DOI: 10.1016/j.nbd.2020.104759

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