Progressive central cardiorespiratory rate downregulation and intensifying epilepsy lead to sudden unexpected death in epilepsy in mouse model of the most common human ATP1A3 mutation.

doi:10.1111/epi.18236

Article

Progressive central cardiorespiratory rate downregulation and intensifying epilepsy lead to sudden unexpected death in epilepsy in mouse model of the most common human ATP1A3 mutation.

Epilepsia - 1 Mar 2025

Hunanyan Arsen S, Verma Amitesh, Bidzimou Minu-Tshyeto, Biswas Debolina D, Da Cruz Emily, Srour Meredith K, Marek Joshua, Hume Cordelia, Elmallah Mai K, Landstrom Andrew P, Mikati Mohamad A

Abstract excerpt

OBJECTIVE: This study was undertaken to test the following hypotheses in the Atp1a3Mashl/+ mouse (which carries the most common human ATP1A3 (the major subunit of the neuronal Na+/K+-adenosine triphosphatase [ATPase]) mutation, D801N): sudden unexpected death in epilepsy (SUDEP) occurs during seizures and is due to terminal apneas in some and due to lethal cardiac arrhythmias in others; and Atp1a3Mashl/+ mice...

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Progressive central cardiorespiratory rate downregulation and intensifying epilepsy lead to sudden unexpected death in epilepsy in mouse model of the most common human ATP1A3 mutation.

Abstract excerpt

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