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Article

Low-Pass Whole-Genome Sequencing as a Method of Determining Copy Number Variations in Uveal Melanoma Tissue Samples.

The Journal of molecular diagnostics : JMD - 1 Mar 2020

Beasley Aaron B, Bentel Jacqueline, Allcock Richard J N, Vermeulen Tersia, Calapre Leslie, Isaacs Timothy, Ziman Melanie R, Chen Fred K, Gray Elin S

Abstract excerpt

Analysis of specific somatic copy number alterations (SCNAs) using multiplex ligation-dependent probe amplification (MLPA) is used routinely as a prognostic test for uveal melanoma (UM). This technique requires relatively large amounts of input DNA, unattainable from many small fine-needle aspirate biopsy specimens. Herein, we compared the use of MLPA with whole-genome amplification (WGA) combined with low-pass...

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Identifiers

PMID: 31978561
DOI: 10.1016/j.jmoldx.2019.12.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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