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Article

Digital PCR validates 8q dosage as prognostic tool in uveal melanoma.

PloS one - 1 Jan 2015

Versluis Mieke, de Lange Mark J, van Pelt Sake I, Ruivenkamp Claudia A L, Kroes Wilma G M, Cao Jinfeng, Jager Martine J, Luyten Gre P M, van der Velden Pieter A

Abstract excerpt

BACKGROUND: Uveal melanoma (UM) development and progression is correlated with specific molecular changes. Recurrent mutations in GNAQ and GNA11 initiate UM development while tumour progression is correlated with monosomy of chromosome 3 and gain of chromosome 8q. Hence, molecular analysis of UM is useful for diagnosis and prognosis. The aim of this study is to evaluate the use of digital PCR (dPCR) for molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25764247
DOI: 10.1371/journal.pone.0116371
PMCID: PMC4357379

Genes

GNA11
GNAQ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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