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Crystallographic analysis of Staphylococcus aureus LcpA, the primary wall teichoic acid ligase

22 Jan 2020

Abstract excerpt

-positive bacteria, including major clinical pathogens such as Staphylococcus aureus, are becoming increasingly drugresistant. Their cell walls are composed of a thick layer of peptidoglycan (PG) modified by the attachment of wall teichoic acid (WTA), an anionic glycopolymer that is linked to pathogenicity and regulation of cell division and PG synthesis. The transfer of WTA from lipid carriers to PG, catalyzed...

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PMID: 31969390
DOI: 10.1074/jbc.ra119.011469

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