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Article

Crystallographic analysis of TarI and TarJ, a cytidylyltransferase and reductase pair for CDP-ribitol synthesis in Staphylococcus aureus wall teichoic acid biogenesis.

Journal of structural biology - 1 Jun 2021

Li Franco K K, Gale Robert T, Petrotchenko Evgeniy V, Borchers Christoph H, Brown Eric D, Strynadka Natalie C J

Abstract excerpt

The cell wall of many pathogenic Gram-positive bacteria contains ribitol-phosphate wall teichoic acid (WTA), a polymer that is linked to virulence and regulation of essential physiological processes including cell division. CDP-ribitol, the activated precursor for ribitol-phosphate polymerization, is synthesized by a cytidylyltransferase and reductase pair known as TarI and TarJ, respectively. In this study, we...

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PMID: 33819634
DOI: 10.1016/j.jsb.2021.107733

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