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Article

Identification and structural characterization of LytU, a unique peptidoglycan endopeptidase from the lysostaphin family.

Scientific reports - 20 Jul 2017

Raulinaitis Vytas, Tossavainen Helena, Aitio Olli, Juuti Jarmo T, Hiramatsu Keiichi, Kontinen Vesa, Permi Perttu

Abstract excerpt

We introduce LytU, a short member of the lysostaphin family of zinc-dependent pentaglycine endopeptidases. It is a potential antimicrobial agent for S. aureus infections and its gene transcription is highly upregulated upon antibiotic treatments along with other genes involved in cell wall synthesis. We found this enzyme to be responsible for the opening of the cell wall peptidoglycan layer during cell divisions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28729697
DOI: 10.1038/s41598-017-06135-w
PMCID: PMC5519744

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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