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Article

TOR ‐mediated regulation of metabolism in aging

2 Oct 2017

Abstract excerpt

Cellular metabolism is regulated by the mTOR kinase, a key component of the molecular nutrient sensor pathway that plays a central role in cellular survival and aging. The mTOR pathway promotes protein and lipid synthesis and inhibits autophagy, a process known for its contribution to longevity in several model organisms. The nutrient-sensing pathway is regulated at the lysosomal membrane by a number of proteins...

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PMID: 28971552
DOI: 10.1111/acel.12689

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