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Murine germ cell-specific disruption of Ift172 causes defects in spermiogenesis and male fertility

20 Jan 2020

Abstract excerpt

Intraflagellar transport (IFT) is a conserved mechanism essential for the assembly and maintenance of most eukaryotic cilia and flagella. IFT172 is a component of the IFT complex. Global disruption of mouse Ift172 gene caused typical phenotypes of ciliopathy. Mouse Ift172 gene appears to translate two major proteins; the full-length protein is highly expressed in the tissues enriched in cilia and the smaller 130...

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PMID: 31958312
DOI: 10.1530/rep-17-0789

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