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Construction of a Promising Tumor-Infiltrating CD8+ T Cells Gene Signature to Improve Prediction of the Prognosis and Immune Response of Uveal Melanoma

28 May 2021

Abstract excerpt

BACKGROUND: CD8+ T cells work as a key effector of adaptive immunity and are closely associated with immune response for killing tumor cells. It is crucial to understand the role of tumor-infiltrating CD8+ T cells in uveal melanoma (UM) to predict the prognosis and response to immunotherapy. MATERIALS AND METHODS: Single-cell transcriptomes of UM with immune-related genes were combined to screen the CD8+...

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PMID: 34124058
DOI: 10.3389/fcell.2021.673838

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