Article
Molecular principles behind pyrazinamide resistance due to mutations in panD gene in Mycobacterium tuberculosis.
Gene - 25 Apr 2016
Pandey Bharati, Grover Sonam, Tyagi Chetna, Goyal Sukriti, Jamal Salma, Singh Aditi, Kaur Jagdeep, Grover Abhinav
Abstract excerpt
The latest resurrection of drug resistance poses serious threat to the treatment and control of the disease. Mutations have been detected in panD gene in the Mycobacterium tuberculosis (Mtb) strains. Mutation of histidine to arginine at residue 21 (H21R) and isoleucine to valine at residue 29 (I49V) in the non-active site of panD gene has led to PZA resistance. This study will help in reconnoitering the mechanism...
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