Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting resident memory T cell immunity culminates in pulmonary and systemic protection against Brucella infection.

PLoS pathogens - 1 Jan 2020

Wang Hongbin, Hoffman Carol, Yang Xinghong, Clapp Beata, Pascual David W

Abstract excerpt

Brucellosis remains the most common zoonotic disease globally. Currently no vaccines for humans exist, and conventional brucellosis vaccines for livestock fail to confer complete protection; hence, an improved vaccine is needed. Although Brucella infections primarily occur following a mucosal exposure, vaccines are administered parenterally. Few studies have considered mucosal vaccinations, or even targeting of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brucella abortus
Share to Brucellosis
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunogenicity, Vaccine

Share to Immunologic Memory

Share to Lung Diseases

Share to Mice, Inbred BALB C

Share to Vaccines, Attenuated

Source

Open in PubMed Open full text

Identifiers

PMID: 31951645
DOI: 10.1371/journal.ppat.1008176
PMCID: PMC6968852

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting resident memory T cell immunity culminates in pulmonary and systemic protection against Brucella infection.PMID 31951645Read ↗

Vaccination with a ΔnorD ΔznuA Brucella abortus mutant confers potent protection against virulent challenge.Semantic proximity Read ↗

Humoral immunity and CD4+ Th1 cells are both necessary for a fully protective immune response upon secondary infection with Brucella melitensis.Semantic proximity Read ↗

T-cell immune responses toBordetella pertussisinfection and vaccination: Graphical Abstract Figure.Semantic proximity Read ↗

Translating innate immunity into immunological memory: implications for vaccine development.Semantic proximity Read ↗

Enhanced immunogenicity of the Brucella A19 ΔbtpB mutant leads to accelerated clearance in the host.Semantic proximity Read ↗

Cytolytic γδ T-cells and IFNγ-producing CD4-lymphocytes characterise the early response to MTBVAC tuberculosis vaccineSemantic proximity Read ↗

Pulmonary-Resident Memory Lymphocytes: Pivotal Orchestrators of Local Immunity Against Respiratory Infections.Semantic proximity Read ↗

A vaccine targeting lung resident-memory CD4+ T cell phenotype protects against Mycobacterium tuberculosis in miceSemantic proximity Read ↗

Control of Mycobacterium tuberculosis Infection in Lungs is Associated with Recruitment of Antigen-Specific Th1 and Th17 cells Co-expressing CXCR3 and CCR6Semantic proximity Read ↗

Pertussis: a matter of immune modulationSemantic proximity Read ↗

<em>Bordetella pertussis</em> Infection: From Immune Pathogenesis to Next-Generation VaccinesSemantic proximity Read ↗

Individuals with latent tuberculosis infection display pulmonary airway enrichment and recall recruitment of CD4+ TRM with protective functional phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.