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Targeting DNA‐Dependent Protein Kinase for Cancer Therapy

19 Apr 2017

Abstract excerpt

The catalytic activity of DNA-dependent protein kinase (DNA-PK) is critical to its ability to repair lethal DNA double-strand breaks (DSBs). This includes repair of DSB lesions resulting from oxidative stress, oncogene-induced transcription, or following therapeutic treatment of cancer cells. Armed with this knowledge, many attempts have been made to identify small-molecule inhibitors of DNA-PK activity as an...

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PMID: 28423228
DOI: 10.1002/cmdc.201700143

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