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Article

Autophagy: an adaptable modifier of tumourigenesis

19 Jan 2010

Abstract excerpt

Recently, autophagy has been demonstrated to modulate tumourigenesis and the response to cancer therapy by regulating numerous cellular functions including maintenance of cell viability under metabolic stress, mitochondrial homeostasis, regulation of reactive oxygen species accumulation, maintenance of genomic integrity, protein quality control, establishment of oncogene-induced senescence and regulation of...

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PMID: 20080398
DOI: 10.1016/j.gde.2009.12.004

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