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Proteogenomic analysis of the Clostridium difficile exoproteome reveals a correlation between phylogenetic distribution and virulence potential.

Anaerobe - 1 Apr 2020

Quesada-Gómez Carlos, Murillo Tatiana, Arce Grettel, Badilla-Lobo Adriana, Castro-Peña Carolina, Molina José, López-Ureña Diana, González-Camacho Sara, Lomonte Bruno, Chacón-Díaz Carlos, Rodríguez Cesar, Chaves-Olarte Esteban

Abstract excerpt

C. difficile induces antibiotic-associated diarrhea due to the action of two secreted toxins, TcdA and TcdB. A considerable range of virulence among C. difficile strains has been widely reported. During a hospital outbreak, 46 isolates were collected that belonged to different genotypes. Of those, the majority corresponded to two virulent strains, the globally distributed Sequence Type 1 (ST1)_North American...

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PMID: 31945474
DOI: 10.1016/j.anaerobe.2020.102151

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