Article
Emergence of an outbreak-associated Clostridium difficile variant with increased virulence.
Journal of clinical microbiology - 1 Apr 2015
Quesada-Gómez Carlos, López-Ureña Diana, Acuña-Amador Luis, Villalobos-Zúñiga Manuel, Du Tim, Freire Rosemayre, Guzmán-Verri Caterina, del Mar Gamboa-Coronado María, Lawley Trevor D, Moreno Edgardo, Mulvey Michael R, de Castro Brito Gerly Anne, Rodríguez-Cavallini Evelyn, Rodríguez César, Chaves-Olarte Esteban
Abstract excerpt
The prevalence of Clostridium difficile infections has increased due to the emergence of epidemic variants from diverse genetic lineages. Here we describe the emergence of a novel variant during an outbreak in a Costa Rican hospital that was associated with severe clinical presentations. This C. difficile variant elicited higher white blood cell counts and caused disease in younger patients than did other strains...
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