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Article

RNA-seq analysis of chondrocyte transcriptome reveals genetic heterogeneity in LG/J and SM/J murine strains.

Osteoarthritis and cartilage - 1 Apr 2020

Duan X, Cai L, Schmidt E J, Shen J, Tycksen E D, O'Keefe R J, Cheverud J M, Rai M F

Abstract excerpt

OBJECTIVE: To investigate the transcriptomic differences in chondrocytes obtained from LG/J (large, healer) and SM/J (small, non-healer) murine strains in an attempt to discern the molecular pathways implicated in cartilage regeneration and susceptibility to osteoarthritis (OA). DESIGN: We performed RNA-sequencing on chondrocytes derived from LG/J (n = 16) and SM/J (n = 16) mice. We validated the expression of...

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Identifiers

PMID: 31945456
DOI: 10.1016/j.joca.2020.01.001
PMCID: PMC7108965

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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