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Monoclonal antibody targeting the conserved region of the SARS-CoV-2 spike protein to overcome viral variants

15 Mar 2022

Abstract excerpt

Most therapeutic mAbs target the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2. Unfortunately, the RBD is a hot spot for mutations in SARS-CoV-2 variants, which will lead to loss of the neutralizing function of current therapeutic mAbs. Universal mAbs for different variants are necessary. We identified mAbs that recognized the S2 region of the spike protein, which is identical in different...

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PMID: 35290246
DOI: 10.1172/jci.insight.157597

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