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Early differentiation patterning of mouse embryonic stem cells in response to variations in alginate substrate stiffness

9 Apr 2013

Abstract excerpt

BACKGROUND: Embryonic stem cells (ESCs) have been implicated to have tremendous impact in regenerative therapeutics of various diseases, including Type 1 Diabetes. Upon generation of functionally mature ESC derived islet-like cells, they need to be implanted into diabetic patients to restore the loss of islet activity. Encapsulation in alginate microcapsules is a promising route of implantation, which can protect...

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PMID: 23570553
DOI: 10.1186/1754-1611-7-9

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