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Article

IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to hydroxyurea in essential thrombocythemia.

Frontiers of medicine - 1 Jun 2022

Huang Xiao, Ma Tingting, Zhu Yongmei, Jiao Bo, Yu Shanhe, Wang Kankan, Mi Jian-Qing, Ren Ruibao

Abstract excerpt

The morbidity and mortality of myeloproliferative neoplasms (MPNs) are primarily caused by arterial and venous complications, progression to myelofibrosis, and transformation to acute leukemia. However, identifying molecular-based biomarkers for risk stratification of patients with MPNs remains a challenge. We have previously shown that interferon regulatory factor-8 (IRF8) and IRF4 serve as tumor suppressors in...

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PMID: 34331664
DOI: 10.1007/s11684-021-0858-1

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IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to hydroxyurea in essential thrombocythemia.PMID 34331664Read ↗

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