Article
A myosin activator improves actin assembly and sarcomere function of human-induced pluripotent stem cell-derived cardiomyocytes with a troponin T point mutation.
American journal of physiology. Heart and circulatory physiology - 1 Jul 2016
Broughton K M, Li J, Sarmah E, Warren C M, Lin Y-H, Henze M P, Sanchez-Freire V, Solaro R J, Russell B
Abstract excerpt
We have investigated cardiac myocytes derived from human-induced pluripotent stem cells (iPSC-CMs) from two normal control and two family members expressing a mutant cardiac troponin T (cTnT-R173W) linked to dilated cardiomyopathy (DCM). cTnT is a regulatory protein of the sarcomeric thin filament. The loss of this basic charge, which is strategically located to control tension, has consequences leading to...
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