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Article

Cryo-EM Structure of Full-length HIV-1 Env Bound With the Fab of Antibody PG16

11 Jan 2020

Abstract excerpt

The HIV-1 envelope protein (Env) is the target of neutralizing antibodies and the template for vaccine immunogen design. The dynamic conformational equilibrium of trimeric Env influences its antigenicity and potential immunogenicity. Antibodies that bind at the trimer apex stabilize a "closed" conformation characteristic of the most difficult to neutralize isolates. A goal of vaccine development is therefore to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Identifiers

PMID: 31931014
DOI: 10.1016/j.jmb.2019.11.028

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